Vitamin B12 Acceptance and Biomarker Response Study

University Hospital Basel

Status and phase

Completed

Phase 4

Conditions

Vitamin B 12 Deficiency

Treatments

Drug: i.m. injection of vitamin B12

Drug: Oral administration of vitamin B12

Study type

Interventional

Funder types

Other

Industry

Identifiers

NCT01832129

PCRG_VB12_CM

Details and patient eligibility

About

In this study, biomarker response after supplementation with oral and intramuscular vitamin B12 will be compared in a randomized clinical trial. Electronic compliance monitoring will be used to control for non compliance as a possible confounder in oral treatment. Additionally subjective acceptance in terms of presumed preferences will be compared with oral vs. intramuscular supplementation of vitamin B12 in the view of the patient.

Enrollment

37 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

General practitioner's prescription for Vitamin B12 deficiency testing
Age> 18 years
Ability to give written informed consent
Vitamin B12 serum concentrations < 200pmol/l
indication for vitamin B12 supplementation according to the General practitioners estimation

Exclusion criteria

Patients with incorrect intake of vitamin preparations containing vitamin B12
Patients with previously diagnosed dementia
Patients with known hereditary transcobalamin transportation defects
lack of written and/or oral understanding in German, French, Italian or English languages