Vitamin B12 and Dextrose for Median Nerve Hydrodissection

National Cheng-Kung University

Status: Enrolling

Conditions: Carpal Tunnel Syndrome

Treatments: Procedure: Ultrasound-guided nerve hydrodissection

Study type: Interventional

Funder types: Other

Identifiers

NCT05423028

NCKUH-11103036

Details and patient eligibility

About

Carpal tunnel syndrome is the most common peripheral entrapment neuropathy of the upper limb. Previous experiments found that ultrasound-guided median nerve hydrodissection with 5% dextrose water could ameliorate the condition of carpal tunnel syndrome. Oral administration of vitamin B 12 had been reported to reduce the discomfort from peripheral neuropathy although the level of evidence is not strong. This prospective, double-blind randomized control trial aims to compare the effects of different kinds of the injection agents on carpal tunnel syndrome.

Enrollment: 120 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age between 20-80 year-old.
• Diagnosis (carpal tunnel syndrome) was confirmed using an electrophysiological study.

Exclusion criteria

• Previously undergone wrist surgery or steroid injection for CTS
• Thrombocytopenia
• Coagulopathy
• Inflammation status
• Polyneuropathy
• Brachial plexopathy
• Cervical radiculopathy
• Autoimmune disease
• Malignancy
• Pregnancy

Thoracic outlet syndrome

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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120 participants in 3 patient groups

Dextrose

Active Comparator group

Treatment:

Procedure: Ultrasound-guided nerve hydrodissection

Vitamin B12

Experimental group

Treatment:

Procedure: Ultrasound-guided nerve hydrodissection

Dextrose + Vitamin B12

Experimental group

Treatment:

Procedure: Ultrasound-guided nerve hydrodissection