Vitamin C as an Adjunct in Periodontal Treatment in Type 2 Diabetes Mellitus Patients

Mahidol University

Status and phase: Unknown; Phase 2

Conditions: Periodontitis; Diabetes Mellitus Type 2 With Hyperglycemia

Treatments: Other: placebo; Drug: Vitamin C 500 MG Oral Capsule

Study type: Interventional

Funder types: Other

Identifiers

NCT03269799

2016/DT068

Details and patient eligibility

About

Periodontitis patients with uncontrolled type 2 diabetes mellitus will receive non-surgical periodontal treatment and then be supplemented with daily 500 mg vitamin C (test group) or placebo (control group) for 2 months. Clinical parameters will be retrieved at baseline, at the end of week 4 and at the end of week 8.

Enrollment: 30 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• uncontrolled type 2 diabetes mellitus
• periodontitis

Exclusion criteria

• complications from diabetes mellitus, e.g., renal insufficiency
• receive insulin
• diseases that interfere with wound healing, e.g., HIV
• receive one of the followings: tetracycline, acetaminophen, NSAID, warfarin, aluminum-containing antacids, barbiturates, phenobarbital, pentobarbital, secobarbital, hormone replacement therapy, chemotherapeutic drug, protease inhibitor
• receive other vitamins or antibiotics within 6 months
• smoking
• pregnancy

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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30 participants in 2 patient groups, including a placebo group

test group

Active Comparator group

Description:

vitamin C 500 mg oral capsule

Treatment:

Drug: Vitamin C 500 MG Oral Capsule

control group

Placebo Comparator group

Description:

placebo

Treatment:

Other: placebo