Vitamin C for the Prevention of UTI in Women Who Undergo Elective Gynecological Surgeries

American University of Beirut Medical Center

Status and phase: Withdrawn; Early Phase 1

Conditions: Catheter-Associated Urinary Tract Infection, Ascorbic Acid

Treatments: Other: Placebo; Drug: Ascorbic Acid 1000 mg

Study type: Interventional

Funder types: Other

Identifiers

NCT04261036

OGY.TB.09/BIO-2017-0609

Details and patient eligibility

About

This open-label randomized trial aims at assessing the role of Vitamin C pills in the prevention of catheter-associated urinary tract infections in women undergoing elective gynecological surgeries.

Sex: Female

Ages: 18 to 90 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Non pregnant women at least 18 years of age visiting the Preadmission unit (PAU) or the OBGYN floor (7N), presenting for elective GYN surgery at the American University of Beirut Medical Center (AUBMC).

Exclusion criteria

• Any women with the following:

  1. Nephrolithiasis
  2. Congenital anomaly or neurogenic bladder
  3. Allergy to ascorbic acid
  4. Who require therapeutic anticoagulant medicine during the 6 weeks after surgery
  5. Surgery did involve a fistula repair or a vaginal mesh removal
  6. Positive Urinalysis in the PAU
  7. Recurrent UTI's
  8. Diabetes
  9. G6PD
  10. Hemochromatosis
  11. Renal disorders

Patients already taking Vitamin C supplementation will also be excluded from the study.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Triple Blind

---

0 participants in 2 patient groups, including a placebo group

Women on a vitamin C regimen

Experimental group

Description:

Women who are undergoing elective gynecological surgeries and who are randomized to take 1g of vitamin C for 14 days.

Treatment:

Drug: Ascorbic Acid 1000 mg

Women on a placebo regimen

Placebo Comparator group

Description:

Women who are undergoing elective gynecological surgeries and who are randomized to take placebo for 14 days

Treatment:

Other: Placebo