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Vitamin C to Reduce Vasopressor Dose in Septic Shock (ViCiS)

H

Hospital Español de Mexico

Status and phase

Withdrawn
Phase 3

Conditions

Septic Shock
Sepsis

Treatments

Drug: Vitamin C
Drug: Placebos

Study type

Interventional

Funder types

Other

Identifiers

NCT03835286
EHE0042

Details and patient eligibility

About

Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.

Patients will be randomized to one of the study groups:

Intervention Group: Vitamin C 6 grams in 250 ml of 0.9% saline solution every 24 hours, in continuous infusion for 72 hours.

Placebo Group: 0.9% saline solution 250 ml every 24 hours, in continuous infusion for 72 hours.

Full description

Randomized, controlled, double blind clinical trial. Adult patients admitted to the ICU of the Hospital Español de México with a diagnosis of septic shock will be included.

Patients will be randomized to one of the study groups:

Intervention Group: Vitamin C 6 grams in 250 ml of 0.9% saline solution every 24 hours, in continuous infusion for 72 hours.

Placebo Group: 0.9% saline solution 250 ml every 24 hours, in continuous infusion for 72 hours.

Bottles will be identical, only identified by the sequential number of the patient that has been included.

Primary objective is to demonstrate that the administration of intravenous Vitamin C decreases the dose of exogenous vasopressors in patients with septic shock

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Adults
  • Septic Shock

Exclusion criteria

  • Previous treatment exceeded 24 hours
  • Refusal to participate
  • Do Not Resuscitate
  • Participation in another trial

Trial design

Primary purpose

Treatment

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Quadruple Blind

0 participants in 2 patient groups, including a placebo group

Vitamin C
Experimental group
Description:
Vitamin C experimental group
Treatment:
Drug: Vitamin C
Control
Placebo Comparator group
Description:
Placebos Controlled group
Treatment:
Drug: Placebos

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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