Vitamin D and Periodontitis

T.C. ORDU ÜNİVERSİTESİ

Status: Completed

Conditions: Alveolar Bone Loss

Treatments: Diagnostic Test: fasting venous blood samples

Study type: Observational

Funder types: Other

Identifiers

NCT03088488

OrduUniversity

Details and patient eligibility

About

Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation. Our aim was to investigate the relation between serum 25-hydroxy vitamin D levels, clinical periodontal parameters and blood serum biomarkers. The subjects were evaluated in 2 groups as chronic periodontitis (n= 30) and periodontally healthy subjects (n= 30). Periodontal parameters and fasting venous blood samples were taken from the subjects to assess each patient's periodontal status and for biochemical analyses (25-hydroxy vitamin D (25-OH vit D), osteoprotegerin (OPG), receptor activator of nuclear kappa B ligand (RANKL), C-telopeptide (CTx), tumor necrosis factor-α (TNF-α)).

Enrollment: 60 patients

Sex: All

Ages: 25 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

• Inclusion Criteria:

  • never-smokers
  • no history of systemic disease
  • no patients had been under periodontal therapy and medicine for at least 6 months before the study
  • no pregnancy or lactation
  • no alcohol or antioxidant vitamin consumption.

• Exclusion Criteria:

Trial design

60 participants in 2 patient groups

Periodontally healthy subjects

Treatment:

Diagnostic Test: fasting venous blood samples

Chronic periodontitis patients

Treatment:

Diagnostic Test: fasting venous blood samples