Vitamin D and Stroke

Assiut University

Status: Completed

Conditions: Stroke

Treatments: Dietary Supplement: Vit D

Study type: Observational

Funder types: Other

Identifiers

NCT02916030

IRB0000871535

Details and patient eligibility

About

Stroke remains one of the most devastating neurological diseases, often causing death, or gross physical impairment. It is the second most common cause of death worldwide and a major cause of acquired disability in adults.Vitamin D deficiency has been reported to contribute to the risk of cardiovascular disease especially stroke.

Full description

This case -control observational prospective study will conducted on fifty patients with first -ever acute onset stroke within seven days (25 patients with hemorrhagic stroke and 25 patients with ischemic stroke )

Enrollment: 50 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Onset is within one week
• Confirmed stroke by brain CAT and / or MRI scan either haemorrhage or infarction

Exclusion criteria

• Cognitive and mental changes
• Recurrent stroke
• Hepatic and renal impairment
• Endocrinal diseases
• Steroid therapy
• Vitamin D or Ca supplementation
• Previous fractures
• Bone diseases
• brain neoplasm,
• Autoimmune diseases
• History of acute and chronic inflammatory diseases
• Malignancy,
• Trauma
• Surgery
• Acute vascular diseases that occurred within four weeks prior the onset of stroke
• History myocardial infarction ˂3 months.

Trial design

50 participants in 2 patient groups

Group 1 (hemorrhagic stroke)

Description:

All participants will be subjected to thorough history taking, full clinical and neurological examination. Stroke subtype will be classified according to the criteria of Trial of Org 10172 in acute Stroke Treatment (TOAST) classification.

Treatment:

Dietary Supplement: Vit D

Group 2 (Ischemic stroke)

Description:

All participants will be subjected to thorough history taking, full clinical and neurological examination. Stroke subtype will be classified according to the criteria of Trial of Org 10172 in acute Stroke Treatment (TOAST) classification.

Treatment:

Dietary Supplement: Vit D