Vitamin D Deficiency and Atopic Dermatitis

Medical College of Wisconsin

Status

Terminated

Conditions

Atopic Dermatitis

Vitamin D Deficiency

Treatments

Drug: Vitamin D

Study type

Interventional

Funder types

Other

Identifiers

NCT01337635

CHW 10/146, GC 1169

Details and patient eligibility

About

Atopic dermatitis is a chronic skin disease characterized by a defective skin barrier, inflammation, and increased propensity for skin infections. Vitamin D is a fat-soluble vitamin that is primarily acquired through local production in the skin after ultraviolet light exposure but can also be obtained through natural and supplemental dietary sources. This randomized controlled trial will examine the effects of vitamin D repletion on atopic dermatitis severity in patients with diagnosed deficiency. The investigators hypothesize that pediatric patients with moderate or severe atopic dermatitis and vitamin D deficiency will have improved cutaneous disease after treatment with high dose as compared to standard dose vitamin D.

Enrollment

7 patients

Sex

All

Ages

1 to 18 years old

Volunteers

No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Serum 25-hydroxyvitamin D level <20 ng/ml (<50 nmol/L)
Diagnosed with atopic dermatitis by a CHW pediatric dermatologist
Age 1-18 years old
Primary residence in Milwaukee County
Moderate and severe atopic dermatitis (Severity Scoring of Atopic Dermatitis [SCORAD] score greater than 15)
On clinic protocol treatment for their atopic dermatitis (desonide ointment twice daily for the face and groin, triamcinolone 0.1% ointment twice daily for other areas)