Vitamin D, Diet and Activity Study (ViDA)

Fred Hutchinson Cancer Center (FHCC)

Status

Completed

Conditions

Breast Cancer

Obesity

Hypovitaminosis D

Treatments

Dietary Supplement: Vitamin D

Dietary Supplement: Placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT01240213

SAC110024

IR 7297 (Other Identifier)

Details and patient eligibility

About

Experimental and human data suggests that vitamin D could protect against breast cancer. Overweight/obese individuals are at increased risk of low vitamin D levels. Vitamin D may reduce production of fat tissue, thereby reducing weight gain, which would result in lower levels of adipose-derived hormones and other breast cancer risk factors.The purpose of this study is to test the effect of vitamin D supplementation on the response to a weight loss (diet + exercise) intervention and select breast cancer risk factors in overweight and obese postmenopausal women with low blood vitamin D levels.

Full description

Objective: To test the incremental effect of vitamin D supplementation (2000 IU/day) in 228 overweight and obese postmenopausal women with low blood vitamin D levels on response to a weight loss (diet + exercise) intervention in a double-blind placebo-controlled clinical trial.

Primary Aim:

• Determine the effects of 12-months vitamin D supplementation vs. placebo on weight loss in women following a weight loss diet and exercise program.

Secondary Aims:

Determine the effects of 12-months vitamin D vs. placebo on blood biomarkers associated with increased breast cancer risk (insulin, glucose, CRP).
Test 12-months vitamin D effects on muscle strength as measured by 1RM leg press and bench press in women undergoing weight loss.
Test the effect of 12-month vitamin D supplementation on effects on quality of life (QOL) in women undergoing weight loss.

Additional Aims:

In a 50% subset of women, test the effect of 12-month vitamin D supplementation vs. placebo on breast epithelial cell cytomorphology (quantified by the Masood cytology index) obtained through random periareolar fine needle aspiration (RPFNA).
Collect subcutaneous abdominal fat aspirations in the 50% subsample of women.

OUTLINE: This is a randomized study. Participants are stratified according to body mass index (< 30 vs ≥ 30) and RPFNA-consent. All participants will receive a 6-month weight loss intervention (prescribed weight loss goal of 10% of initial body weight) followed by 6 months' maintenance therapy.

Baseline, 6-, and 12-month measurements will include weight, BMI, waist and hip circumference, serum 25-hydroxyvitamin D, fasting blood samples, and questionnaires on details of diet especially items containing vitamin D, physical activity levels, sun exposure including clothing and sunscreen habits, dietary supplement and vitamin use, and medications.

Enrollment

218 patients

Sex

Female

Ages

50 to 75 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Age 50-75 years
Postmenopausal (no periods for past 12 months)
Screening serum vitamin D (25(OH)D) between 10 and 32 ng/mL ("insufficient")
No menopausal HRT use of any type including vaginal X 6 months and willing to avoid use for study duration
BMI > 25.0 kg/m2 (> 23.0 for Asians)
Physically able to undertake a calorie reduction and exercise program
Able to come for clinic visits, classes, and measurements, fill out questionnaires and logs in English
Gives informed consent, agrees to be randomly assigned

Exclusion criteria

Currently using more that 400 IU vitamin D from supplemental sources
Screening vitamin D level < 10 ng/mL (will be referred to primary provider) or > 32 ng/mL (already sufficient)
Osteoporosis
Renal disease, history of kidney stones
Any contra-indications to taking vitamin D 2000 IU/day
Plans to leave the study area within the follow-up period
Plans to join another organized weight loss program or take appetite suppressant medication during the study period
History of bariatric surgery
Current use of medications likely to interfere with adherence to interventions or study outcomes
Current smoker
Personal history of invasive or in situ breast cancer
Personal history of invasive cancer other than breast: except for non- melanoma skin cancer which would be eligible
Diabetes mellitus
Abnormalities on screening physical that contraindicate participation
Severe congestive heart failure per NYHA criteria 3 & 4
Contraindications for entry into a research exercise program: recent (within 6 months) myocardial infarction, pulmonary edema, myocarditis, pericarditis, unstable angina, pulmonary embolism, deep vein thrombosis, uncontrolled hypertension (systolic > 200, diastolic > 100), orthostatic hypotension, moderate/severe aortic stenosis, uncontrolled arrythmia, uncontrolled congestive heart failure, left bundle branch block, history of cardiac arrest or stroke
Alcohol or drug abuse, significant mental illness (as assessed by study staff impression)
For the RPFNA/adipose tissue substudy: bilateral breast cancer, bilateral mastectomy, unable or unwilling to stop aspirin or NSAIDs for 1 week before and after the procedure, allergy to anesthetics or local anesthetics.