Vitamin D Influence on Oocyte Donation

IVI Madrid

Status: Completed

Conditions: Disorder of Phosphate, Calcium and Vitamin D Metabolism; Female Infertility Due to Diminished Ovarian Reserve; Reproductive Disorder; Hormonal Requirement

Treatments: Other: vitamin D,AMH, AFC, reproductive outcome egg recipients

Study type: Observational

Funder types: Other

Identifiers

NCT02341365

1406-MAD-035-JG

Details and patient eligibility

About

Objective: To investigate the correlation between total and bioavailable serum 25-OH vitamin D, ovarian reserve and ovarian response to controlled stimulation in egg donors.

Full description

Design: Retrospective study. Setting: University affiliated private IVF center. Intervention: Serum analysis of vitamin D, bioavailable vitamin D, antimullerian hormone (AMH), antral follicular count (AFC), reproductive outcome of oocytes recipients Main outcome measure: AMH, AFC, number of oocytes retrieved and number of mature oocytes, pregnancy and implantation rate of donated oocytes'recipients.

Enrollment: 269 patients

Sex: Female

Ages: 18 to 34 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Caucasian race,
• between 18 and 34 years of age,
• all donors had normal menstrual cycles of 26-34 days,
• normal weight range (BMI 18- 25 Kg/m2),
• normal uterus and ovaries on transvaginal ultrasound (no signs of polycystic ovarian syndrome), and
• an antral follicle count (AFC) >10,
• normal karyotype

Exclusion criteria

• current or past exposure to radiation or hazardous chemical substances,
• history of drug use,
• family history of hereditary chromosomal diseases,
• sexually transmitted diseases