Vitamin D Level and Its Relation to Pre-eclampsia and Eclampsia

Cairo University (CU)

Status: Unknown

Conditions: Pre-Eclampsia; Eclampsia, Antepartum; Vitamin D Deficiency

Treatments: Diagnostic Test: Determination of Vitamin D by ELISA

Study type: Observational

Funder types: Other

Identifiers

NCT03882099

173019OBGYN

Details and patient eligibility

About

To compare 25(OH)D level in patients with pre-eclampsia, eclampsia and normotensive pregnant women as well as to study the prevalence of Vitamin D deficiency among the 3 groups.

Full description

200 patients with pre-eclampsia, 100 with eclampsia and 200 normotensive pregnant controls attending Delivery/emergency department in Kasr Al Ainy hospital will be included in the study (from March 2019 till September 2019). 25(OH) D level will be measured for the three groups.

• Preeclampsia is defined as systolic BP >140 and/or diastolic BP>90 on two occasions, 4 hours apart in pregnant females>20 weeks, plus proteinuria >/= 1+ urine dipstick protein.
• Eclampsia defined as tonic-clonic seizures in women with pre-eclampsia.
• Controls are normotensive pregnant females with no proteinuria and no other medical disorders.
• The determination of 25(OH) D is based on a competitive enzyme-linked immunosorbant assay (ELISA) using the 25(OH)D3/D2 ELISA system (ORGENTIC DIAGNOSTIKA GmbH, Germany)

Inclusion criteria:

Age 20-35 years Gestational age 30-40 weeks

Exclsion criteria:

Twin pregnancy Other medical conditions during prrgnancy Drugs that influence Vit D levels eg.antiepileptics and antituberculous treatment.

Enrollment: 500 estimated patients

Sex: Female

Ages: 20 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Age 20-35 years
• Gestational age 30-40 weeks

Exclusion criteria

• Twin pregnancy
• Other medical conditions during pregnancy
• Drugs that influence Vit D levels eg.antiepileptics and antituberculous treatment

Trial design

500 participants in 3 patient groups

Pregnant women with pre-eclampsia

Treatment:

Diagnostic Test: Determination of Vitamin D by ELISA

Pregnant women with eclampsia

Treatment:

Diagnostic Test: Determination of Vitamin D by ELISA

Normotensive pregnant women

Treatment:

Diagnostic Test: Determination of Vitamin D by ELISA