Vitamin D Levels and Postoperative Hypocalcemia After Total Thyroidectomy

Aristotle University Of Thessaloniki

Status: Unknown

Conditions: Vitamin D Deficiency; Thyroidectomy; Hypocalcemia; Hypoparathyroidism

Study type: Observational

Funder types: Other

Identifiers

NCT01039714

GXKVITD1

Details and patient eligibility

About

Hypocalcemia is one of the most frequent complications of total thyroidectomy, a procedure used for benign as well as malignant conditions of the thyroid gland. Postoperative hypocalcemia is usually caused by hypoparathyroidism. Vitamin D is implicated in calcium metabolism as it increases intestinal calcium transport and regulates parathormone production. Aim of the present study is to evaluate preoperative vitamin D levels as a prognostic factor for postoperative hypocalcemia and hypoparathyroidism.

Enrollment: 200 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

1. Patient is over 18 years old
2. Patient scheduled for total thyroidectomy
3. Patient signs and dates a written informed consent form (ICF) and indicates an understanding of the study procedures

Exclusion criteria

1. Primary hyperparathyroidism
2. Primary hypoparathyroidism
3. Chronic Renal Failure
4. Hypoalbuminemia
5. Neck irradiation
6. Systematic Diseases (e.g., infections)
7. Thyroid or parathyroid cancer
8. Osteoporosis
9. Drugs that influence calcium metabolism (vitamin D analogues, oral calcium supplements, biphosphonates, teriparatide, thiazide diuretics)

Trial design

200 participants in 1 patient group

Total Thyroidectomy