VITAMIN D METABOLITES AS BIOMARKERS FOR THE IDENTIFICATION OF KIDNEY INJURY IN CARDIAC SURGERY (VITAL)

University Health Network, Toronto

Status: Not yet enrolling

Conditions: Chronic Renal Diseases; Acute Kidney Injuries

Study type: Observational

Funder types: Other

Identifiers

NCT06688994

23-6027

Details and patient eligibility

About

We will be measuring vitamin D metabolites in blood samples drawn from patients undergoing cardiac surgery to determine the correlation with renal function as assessed by serum creatinine. We will include 20 patients in each of the following 3 groups based on serum creatinine measured within 28-days of surgery: 1) normal kidney function (eGFR > 60 mL/min, n=20), 2) moderate impaired kidney function, eGFR between 30 and 60 mL/min (n=20) and 3) severe kidney dysfunction eGFR < 30 mL/min (n=20).

Enrollment: 60 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria

• ≥ 18 years
• Patients undergoing cardiac surgery
• Serum Creatinine measured with 28 days of surgery

Exclusion Criteria

• Exogeneous calcitriol (1,25(OH)2D3) intake
• History of parathyroidectomy
• Patients with liver or kidney cancer
• Patients with liver disease (e.g. liver failure, cirrhosis)