Vitamin D Supplement Study for Stage Three and Four Chronic Kidney Disease (CKD) Patients (UPGRADE)

NeuroTherapia, Inc.

Status and phase

Terminated

Phase 3

Conditions

Chronic Kidney Disease Stage 3 and 4

Treatments

Drug: Ergocalciferol

Drug: Cholecalciferol

Study type

Interventional

Funder types

Other

Identifiers

NCT01173848

Cleveland Clinic

Details and patient eligibility

About

The purpose of this study is to examine the effectiveness of vitamin D3 versus vitamin D2 in raising vitamin D levels and suppressing parathyroid hormone levels in patients with kidney disease who are not on dialysis.

Full description

Subjects will be randomized and assigned to one of the treatment groups (D2 or D3). Subjects will be dispensed a supply of 1.25 mg cholecalciferol/ergocalciferol tablets, depending on their randomization outcome. The number of pills dispensed and medication instructions will be determined by their 25OHD level and K/DOQI guidelines. Both Study personnel and subject will be blinded to randomization group.

The treatment phase will be 24 weeks in duration with lab visits every 6 weeks. All laboratory specimens will be drawn either at CCF Main hospital labs or at a CCF family Health center lab. Subjects will be have telephone interviews at week 4, 10, 16, 22 and possibly at weeks 28 and 34.

Enrollment

19 patients

Sex

All

Ages

18 to 99 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Adults ≥ 18 years
Chronic kidney disease stage 3-4 (eGFR 15-59 mL/min/1.73m2 body surface area, calculated using the MDRD Study equation GFR calculator)
Hypovitaminosis D (serum 25OHD < 31 ng/mL)
Secondary hyperparathyroidism (Intact PTH > 70 pg/mL for stage 3, and iPTH > 110 pg/mL for stage 4)

Exclusion criteria

Initiation of vitamin D therapy between the time of the lab draw used for screening and the screening process
History of liver failure
History of intestinal malabsorption or chronic diarrhea
Serum calcium level greater than 10.2 mg/dL
Treatment with an activated vitamin D formulation (calcitriol, doxercalciferol or paricalcitol) within the past 6 months
Treatment with phenobarbital, phenytoin, rifampicin, sucralfate, steroids, digoxin, or other medications that could affect vitamin D metabolism
Primary hyperparathyroidism, active of a prior history of such
Active malignancy excluding basal cell or localized squamous cell skin cancer
Subject is pregnant (e.g. positive HCG test) or breast-feeding
Refusal to use highly effective contraceptive measures (as determined by the investigator) throughout the treatment phase of the study
Serum phosphorus level greater than 4.5 or treatment with an oral phosphate binder within the past 6 months
Treatment with cinacalcet or other calcimimetic within the past 6 months
Anticipated dialysis within 6 months after randomization
Inability to swallow tablets
Known sensitivity, intolerance, or other adverse response to the study drugs which would prevent compliance with study medication
Have an unstable medical condition, defined as having been hospitalized within 30 days before screening, the expectation of recurrent hospital admissions or life expectancy of less than 6 months in the judgment of the investigator
Subject is currently enrolled in, or fewer than 30 days have passed since subject has completed another investigational device or drug study(s); or subject is receiving another investigational agent(s).
Current treatment with vitamin D 50,000 IU