Vitamin D Supplementation and Immunity/Physical Performance

Bangor University

Status: Unknown

Conditions: Vitamin D Status

Treatments: Dietary Supplement: Oral Vitamin D3; Radiation: Solar simulated radiation (SSR); Dietary Supplement: Placebo Oral Vitamin D3; Radiation: Placebo SSR

Study type: Interventional

Funder types: Other

Identifiers

NCT03132103

692/Gen/10

Details and patient eligibility

About

The purpose of this study is to examine the effect of vitamin D supplementation on vitamin D status, immunity and physical performance.

Full description

Vitamin D plays a key role in bone mineralisation and has been linked to immune defence maintenance and muscle function. Vitamin D is primarily obtained from endogenous synthesis in response to skin sunlight exposure and follows a seasonal pattern; whereby, vitamin D levels peak at the end of the summer and fall to a trough during winter. If winter vitamin D levels can be increased to match those found in summer using supplementation, it is proposed sufficient vitamin D levels will improve physical performance and reduce susceptibility to illness in military recruits.

Enrollment: 260 estimated patients

Sex: Male

Ages: 17 to 35 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Passed medical assessment by medical doctor

Exclusion criteria

• Medically deferred by medical doctor
• Regular sun bed use
• Holiday in a hot sunny climate in <3 months
• Regular vitamin D supplementation

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Double Blind

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260 participants in 4 patient groups, including a placebo group

Solar simulated radiation (SSR)

Experimental group

Description:

Solar simulated radiation (SSR)

Treatment:

Radiation: Solar simulated radiation (SSR)

Placebo SSR

Placebo Comparator group

Description:

Placebo SSR

Treatment:

Radiation: Placebo SSR

Oral Vitamin D3

Experimental group

Description:

Oral Vitamin D3

Treatment:

Dietary Supplement: Oral Vitamin D3

Placebo Oral Vitamin D3

Placebo Comparator group

Description:

Placebo Oral Vitamin D3

Treatment:

Dietary Supplement: Placebo Oral Vitamin D3