Vitamin D Supplementation in Critically Ill Children With Respiratory Disease

Assiut University

Status: Not yet enrolling

Conditions: Vitamin D Supplementation

Study type: Observational

Funder types: Other

Identifiers

NCT06547749

Vitamin D supplementation

Details and patient eligibility

About

To evaluate the role of vitamin D supplementation in critically ill children with respiratory disease regarding their outcome.

Full description

Vitamin D is involved in the process of immunomodulation, especially in the context of autoimmunity . Vitamin D has multiple pharmacological effects, such as alleviating the inflammatory response, promoting phagocytosis, and inducing lymphocyte proliferation . previous studies have demonstrated that patients with lower serum vitamin D levels had a longer length of hospital stay and might have an independent relationship with the duration of mechanical ventilation (MV) in critically ill children

.

Approved Vitamin D Supplementation Regimens:

The recommended daily allowance (RDA) or adequate intake (AI) suggested by the Institute of Medicine (IOM) and supported by Health Canada are 400 IU for infants and 600 IU for older children.

Approved High-Dose Regimens:

In addition to RDA, the IOM provides a higher age-specific dose called the tolerable upper intake level (UL), which ranges from 1,000 to 4,000 IU.

Enrollment: 40 estimated patients

Sex: All

Ages: 1 month to 16 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All pediatric patients admitted in PICU with respiratory disease with age from 1month to 16 years.

Exclusion criteria

• Patients admitted in PICU due to causes rather than respiratory disease.