Vitamin D Supplementation in Vitamin Deficient Women Undergoing IVF Cycles: Does it Affect the Fertility Outcome?

Cairo University (CU)

Status and phase: Completed; Phase 4

Conditions: Infertility

Treatments: Drug: Vitamin D

Study type: Interventional

Funder types: Other

Identifiers

NCT03209856

3645

Details and patient eligibility

About

The aim of this study is to evaluate the effect of treatment of vitamin D deficiency (through vitamin D supplementation for 8 weeks before the start of In-vitro fertilization (IVF) on the success of IVF cycles.

Full description

The study participants are vitamin D deficient females undergoing (intra-cytoplasmic sperm injection (ICSI) trial in the age of 20 to 35 years. Serum vitamin D will be assessed. Accordingly, if they are deficient in vitamin D, they will be eligible for the study.400 vitamin D deficient women will be randomly allocated to either one of two groups. The first group will receive vitamin D supplementation in addition to the routine care. The other group will receive the routine care only. The study will be conducted in the IVF unit of department of Obstetrics and Gynecology, Cairo University.

Enrollment: 200 patients

Sex: Female

Ages: 20 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Vitamin D deficient females undergoing first ICSI trial
• Age from 20 to 35 years

Exclusion criteria

• Women undergoing ICSI trials who are vitamin D sufficient

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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200 participants in 2 patient groups

Vitamin D supplement

Experimental group

Description:

This group will receive weekly oral 50000 international units of vitamin D supplement for 8 weeks before the start of ICSI cycle. In addition, the routine care will be given.

Treatment:

Drug: Vitamin D

Routine care

No Intervention group

Description:

This group will receive the routine care.