Vitamin D Supplementation Prevents Elderly Pneumonia

T

Tohoku University

Status

Completed

Conditions

Bacterial Pneumonia

Treatments

Dietary Supplement: Vitamin D3

Study type

Interventional

Funder types

Other

Identifiers

NCT00877422
KAKENHI 20390285
IDAC-VD-01

Details and patient eligibility

About

Pneumonia is the fourth leading cause of death and frequently occurs in institutionalized elderly people in Japan. Recently, several clinical and experimental studies have reported the importance of vitamin D in the regulation of immune functions and its deficiency is associated with susceptibility to some infections. In the present study, the investigators hypothesize that deficiency of serum vitamin D is associated with development of pneumonia, and supplementation of vitamin D may lower the incidence of pneumonia and prolong survival in institutionalized elderly subjects.

Enrollment

100 patients

Sex

All

Ages

65+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Subjects are more than 65 years old and were resident in the facility for at least 6 months.
  • Subjects have no conditions known to interfere with vitamin D metabolism.

Exclusion criteria

  • Subjects are excluded if they have:

    • renal failure
    • hepatic failure
    • hyper- or hypo-parathyroidism
    • HIV infection, or malignant diseases
  • Subjects are also excluded if they are taking corticosteroid, thiazide diuretics, or supplementary vitamins.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Parallel Assignment

Masking

Single Blind

100 participants in 3 patient groups

Group A
No Intervention group
Description:
Group A is identified as serum vitamin D level more than 16 ng/dl.
Group B
Active Comparator group
Description:
Group B is identified as serum vitamin D level less than 16 ng/dl and is supplemented with vitamin D3.
Treatment:
Dietary Supplement: Vitamin D3
Group C
No Intervention group
Description:
Group C is identified as serum vitamin D less than 16 ng/dl and is not supplemented with vitamin D3.

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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