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Vitamin D Supplementation Reduces Renin-Angiotensin System Activity in Obesity

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Mass General Brigham

Status

Completed

Conditions

Hypertension
Vitamin D Deficiency
Obesity

Treatments

Dietary Supplement: Vitamin D (cholecalciferol)

Study type

Interventional

Funder types

Other

Identifiers

NCT01068418
2009p002062

Details and patient eligibility

About

Hypothesis: Vitamin D supplementation lower renin-angiotensin system activity in obesity.

Specific Aim: To investigate whether Vitamin D supplementation in obesity improves the vascular sensitivity to angiotensin II.

Full description

Vitamin D deficiency and obesity are international epidemics that have both been associated with increased activity of the renin-angiotensin system (RAS). Because increased RAS activity is associated with cardiovascular disease, interventions to lower RAS will have favorable public health impacts.

This study aims to evaluate whether the supplementation of Vitamin D in obese subjects will lower local tissue RAS activity. RAS activity will be evaluated by cross-sectional measurement of RAS components and by quantifying the vascular response to an infusion of angiotensin II. Subjects will be studied while Vitamin D deficient, and will return for repeat study following Vitamin D supplementation, for comparison.

Enrollment

26 patients

Sex

All

Ages

18 to 64 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • age < 65,
  • Cr < 1.6,
  • 25-hydroxyvitamin D < 25 ng/mL,
  • BMI > 30 kg/m2,
  • stage I hypertension.

Exclusion criteria

  • diabetes,
  • coronary heart disease,
  • heart failure,
  • renal failure,
  • liver failure,
  • hyperparathyroidism,
  • granulomatous disease.

Trial design

Primary purpose

Other

Allocation

N/A

Interventional model

Single Group Assignment

Masking

None (Open label)

26 participants in 1 patient group

Vitamin D3
Experimental group
Description:
15000IU of vitamin D3 daily: open-label, single-arm
Treatment:
Dietary Supplement: Vitamin D (cholecalciferol)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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