Vitamin D Supplementation to Obese Chinese Males

Shenzhen Center for Chronic Disease Control

Status: Completed

Conditions: Insulin Resistance; Obesity

Treatments: Dietary Supplement: Oral supplementation of vitamin D

Study type: Interventional

Funder types: Other

Identifiers

NCT01781169

VD50kIU2011

Details and patient eligibility

About

Hypothesis: Oral Supplementation of Vitamin D can Reduce Hypersecretion of Parathyroid Hormone and Insulin Resistance in Obese Chinese Males.

Protocol: Weekly oral supplementation of 50,000 IU vitamin D (cholecalciferol) or eight weeks to the obese males compared with the normal-weight males. Index measures were conducted at baseline and endpoint.

Enrollment: 43 patients

Sex: Male

Ages: 23 to 66 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• body mass index (BMI) ≥ 28kg/m2 or 18.5 ≤ BMI < 24 (kg/m2)
• non vegetarian Han Chinese and did not smoke, drink, nor take vitamin D supplements for > 2 y
• fasting serum glucose < 7.0 mmol/L
• serum glucose of 2 hr after 75 g oral glucose loading < 11.1 mmol/L
• normal functioning of liver and kidney evaluated by alkaline phosphatase, aspartate aminotransferase, creatinine, and uric acid

Exclusion criteria

• not match the above inclusion criteria
• diagnosed as having any organic diseases were excluded

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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43 participants in 2 patient groups

Obese group

Experimental group

Description:

Oral supplementation of vitamin D (cholecalciferol), 50000 IU/wk for 8 weeks.

Treatment:

Dietary Supplement: Oral supplementation of vitamin D

Normal-weight group

Experimental group

Description:

Oral supplementation of vitamin D (cholecalciferol), 50000 IU/wk for 8 weeks.

Treatment:

Dietary Supplement: Oral supplementation of vitamin D