Vitamin K-absorption From Dairy

Maastricht University Medical Centre (MUMC)

Status: Completed

Conditions: Healthy

Treatments: Dietary Supplement: vitamin K-rich dairy product

Study type: Interventional

Funder types: Other

Identifiers

NCT00931437

08-3-086

Details and patient eligibility

About

Lactic acid bacteria produce a mixture of higher menaquinones, including menaquinone-9 (MK-9) and menaquinone-10 (MK-10). Vitamin K1 (phylloquinone) is normally present in chloroplasts in green vegetables. A new dairy product is developed containing both vitamin K1 and K2-vitamins. However, the extent to which the various forms of vitamin K are absorbed from such a mixture is not known. In this study the absorption profile of phylloquinone and menaquinones from this new dairy product containing several K-vitamins is investigated. This study describes a dietary intervention experiment for one single cocktail containing several K-vitamins as part of a dairy product.

Enrollment: 12 patients

Sex: All

Ages: 20 to 45 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Healthy men and women between 20 and 45 years old
• Subjects of normal body weight and height according to BMI < 30
• Subjects of Caucasian race
• Subject has given written consent to take part in the study

Exclusion criteria

• Subjects with (a history of) metabolic or gastrointestinal disease
• Subjects presenting chronic degenerative and/or inflammatory disease
• Abuse of drugs and/or alcohol
• Subjects receiving corticoid treatment
• Subjects using oral anticoagulants

Trial design

Primary purpose: Treatment

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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12 participants in 1 patient group

vitamin K-rich dairy product

Experimental group

Description:

one single intake of a dairy product containing several K-vitamins: phylloquinone, menaquinone-7,8,9-and 10.

Treatment:

Dietary Supplement: vitamin K-rich dairy product