Vitreous Level Of Tumor Necrosis Factor Alpha In Patients With Retinal Vein Occlusion

Kasr El Aini Hospital

Status: Completed

Conditions: Retinal Vein Occlusion

Treatments: Diagnostic Test: measurement of vitreous level of tumor necrosis factor alpha

Study type: Observational

Funder types: Other

Identifiers

NCT05532475

MS-654-2021

Details and patient eligibility

About

To assess the levels of TNF- α in vitreous samples of patients with retinal vein occlusion prior to administration of intravitreal anti-VEGF and compare them to levels in vitreous samples of normal subjects so as to investigate the association of vitreous tumor necrosis factor with the pathogenesis of retinal vein occlusion.

Enrollment: 40 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Any patient with retinal vein occlusion not older than 6 months with no history of Anti-VEGF injection

Exclusion criteria

1. Diabetic patients.
2. Other causes of retinal vascular diseases.
3. Patients with history of treatment of retinal vein occlusion.
4. Previous intraocular surgery except cataract surgery performed 6 months before the study.
5. Subjects with severe systemic inflammatory diseases
6. Retinal vein occlusion secondary to retinal vasculitis.
7. All retinal pathologies.
8. Patients receiving Systemic steroids or Immunosuppressive therapy.

Trial design

40 participants in 2 patient groups

cases

Description:

patient with retinal vein occlusion

Treatment:

Diagnostic Test: measurement of vitreous level of tumor necrosis factor alpha

control

Description:

cataract patient undergoing cataract surgery

Treatment:

Diagnostic Test: measurement of vitreous level of tumor necrosis factor alpha