Vitrification Versus Spontaneous Conception and Slow- Rate Freezing

University of Luebeck

Status: Completed

Conditions: Pregnancy

Treatments: Other: Observation

Study type: Observational

Funder types: Other

Identifiers

NCT01088425

UKSH-HL-09-195

09-195 (Registry Identifier)

Details and patient eligibility

About

Great scientific effort has been made to improve practical as well as economical procedures of modern assisted reproduction.

In the last years a shift from the well established method of slow-rate freezing to vitrification of 2PN zygotes and embryos could be observed. Like any other method of cryopreservation, the outcome of vitrification will be affected by several factors related to technique itself, its practical management and patient characteristics.

The investigators want to investigate the influence of vitrification on the outcome of of 2PN oocytes, pregnancy and infant health.

A Comparison between a cohort of spontaneous conceived children and children of vitrified and slow- cooled 2PN oocytes is planned.

Enrollment: 850 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• cryopreservation (vitrification and slow- rate freezing) between 1998 - 2010
• Treatment in Lübeck University
• Delivery in Lübeck University
• Positive informed consent

Exclusion criteria

• Negative informed consent

Trial design

850 participants in 3 patient groups

Spontaneous

Description:

Mothers with children conceived after spontaneous cycle

Treatment:

Other: Observation

Vitrificatíon

Description:

Mothers with children conceived after vitrification cycle

Treatment:

Other: Observation

slow- rate freezing

Description:

Mothers with children conceived after slow- rate freezing cycle

Treatment:

Other: Observation