VLDL-triglyceride Kinetics in Type 2 Diabetes

University of Aarhus

Status: Completed

Conditions: Type 2 Diabetes

Treatments: Other: Hyperinsulinemic euglycemic glucose clamp

Study type: Observational

Funder types: Other

Identifiers

NCT01037647

20070028

Details and patient eligibility

About

Type 2 diabetes is associated with diabetic dyslipidemia, which is a major risk factor for coronary heart disease. Triglycerides (TG) and cholesterol are transported in the system of lipoproteins, and the metabolism of these lipids in plasma is closely interrelated. Evidence suggests that increased concentration of very low-density lipoprotein triglyceride (VLDL-TG) is a central pathophysiological feature of the lipid and lipoprotein abnormalities in diabetic dyslipidemia.

The objective of this study was to investigate VLDL-TG kinetics and aspects of peripheral VLDL-TG metabolism, i.e. to what extent VLDL-TG associated fatty acids (FA) are oxidized or deposited in regional adipose tissue, in subjects with type 2 diabetes and healthy controls in the postabsorptive state and during acute hyperinsulinemia using ex-vivo labeled VLDL-TG tracers.

Enrollment: 22 patients

Sex: Male

Ages: 20 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

Exclusion Criteria:

• Known disease except type 2 diabetes (type 2 diabetic subjects)
• Smoking
• Alcohol abuse
• Prescription medication expect oral antidiabetics (type 2 diabetic subjects)

Trial design

22 participants in 2 patient groups

Type 2 diabetic men

Description:

Men with type 2 diabetes

Treatment:

Other: Hyperinsulinemic euglycemic glucose clamp

Healthy men

Description:

Healthy men

Treatment:

Other: Hyperinsulinemic euglycemic glucose clamp