VOCs in Patients With Acute Cardiogenic Chest Pain

Shandong University

Status: Enrolling

Conditions: Acute Aortic Syndrome; Acute Coronary Syndrome

Treatments: Diagnostic Test: VOCs

Study type: Interventional

Funder types: Other

Identifiers

NCT06277895

KYLL-202401-047

Details and patient eligibility

About

The goal of this observation study is to compare VOCs in cardiogenic chest pain population/health conditions, to answer：Establishment and promotion of the application system of emergency rapid detection of expiratory Volatile Organic Compounds (VOCs) in patients with acute cardiogenic chest pain

1. VOCs levels were measured at baseline in healthy people, and markers of VOCs that could be used to identify acute cardiogenic chest pain were sought.
2. The relationship between abnormal VOCs (mainly aldehydes) and prognosis of patients and the correlation with Super-score for early warning of acute heart failure.

Enrollment: 1,400 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Observation group inclusion criteria:

1. Over 18 years old, male or female;
2. Patients with acute cardiogenic chest pain (see diagnostic criteria);
3. Patient's informed consent.

Inclusion criteria of healthy control group:

1. Over 18 years old, male or female;
2. Centerless cerebrovascular disease, lung disease, no abnormal liver and kidney function, no acute infection recently;
3. Informed consent.

Exclusion criteria

1. The patient had difficulty in collecting breath;
2. Patients with terminal illness or receiving palliative care;
3. Have participated in other clinical studies or consider it inappropriate to participate in this study.

Trial design

Primary purpose: Diagnostic

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,400 participants in 2 patient groups

cardiogenic chest pain group

Experimental group

Description:

cardiogenic chest pain group/acute coronary syndrome

Treatment:

Diagnostic Test: VOCs

normal group

Other group

Description:

Healthy population

Treatment:

Diagnostic Test: VOCs