Volatile Anesthetic Choice and Duration of Hospitalization: A Quality Improvement and Cost-control Project

NeuroTherapia, Inc.

Status: Completed

Conditions: Duration of Hospitalization

Treatments: Drug: Isoflurane; Drug: Sevoflurane

Study type: Interventional

Funder types: Other

Identifiers

NCT01379664

11-440

Details and patient eligibility

About

Preliminary retrospective data suggest that the relatively soluble but inexpensive volatile anesthesia isoflurane prolongs the duration of hospitalization compared to the less soluble but more expensive anesthetic sevoflurane. Even a small reduction in the duration of hospitalization would easily compensate for the modest additional cost of sevoflurane. The investigators therefore propose to test the primary hypothesis that duration of hospitalization is longer with isoflurane than sevoflurane.

The investigators will also test the secondary hypotheses that: 1) pain scores are greater in patients recovering from isoflurane than sevoflurane anesthesia; and, 2) opioid consumption is greater after isoflurane than sevoflurane anesthesia. All statistical analyses will be adjusted for age, gender, race, baseline risk, 9 and procedure.

Enrollment: 1,584 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria:

• Must have surgery in G operating room suite

Trial design

Primary purpose: Health Services Research

Allocation: Non-Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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1,584 participants in 2 patient groups

Isoflurane

Experimental group

Description:

Isoflurane is to be administered to patients in this arm during surgery

Treatment:

Drug: Isoflurane

Sevoflurane

Experimental group

Description:

Sevoflurane is to be administered to patients in this arm during surgery

Treatment:

Drug: Sevoflurane