"Volatile Anesthetic Protection Of Renal Transplants: VAPOR-1-trail

University Medical Center Groningen (UMCG)

Status: Completed

Conditions: Kidney Donation/Transplantation

Treatments: Drug: volatile agent only during reperfusion; Drug: propofol-remifentanil/sufentanil; Drug: procedure:sevoflurane-remifentanil/sufentanil

Study type: Interventional

Funder types: Other

Identifiers

NCT01248871

VAPOR 001

Details and patient eligibility

About

To compare the renal protective properties of two currently used anaesthetic techniques - a sevoflurane-remifentanil/sufentanil combination with a propofol-remifentanil/sufentanil combination for anaesthesia in patients undergoing living donor kidney donation/transplantation.

Enrollment: 120 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients: Age > 18 years

Exclusion criteria

• patient refusal
• BMI< 17, >35
• neurological disorder
• recent use of psycho-active medication, including alcohol.
• Donor-recipient couples from the ABO-incompatible program
• Altruistic donor

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

120 participants in 3 patient groups

SEVO

Active Comparator group

Description:

sevoflurane-remifentanil/sufentanil combination

Treatment:

Drug: procedure:sevoflurane-remifentanil/sufentanil

SERE

Active Comparator group

Description:

volatile agent only during reperfusion

Treatment:

Drug: volatile agent only during reperfusion

propofol

Active Comparator group

Description:

propofol-remifentanil/sufentanil

Treatment:

Drug: propofol-remifentanil/sufentanil