Volatile Organic Compounds (VOCs) of Exhaled Breath in Patients With GI Bleeding

Seoul National University

Status: Unknown

Conditions: Gastrointestinal Hemorrhage; Volatile Organic Compounds

Treatments: Diagnostic Test: Collection of exhaled breath

Study type: Observational

Funder types: Other

Identifiers

NCT04226079

1911-086-107

Details and patient eligibility

About

Cross sectional case-control study investigating the difference of volatile organic compound in the exhaled breath of the patients with GI bleeding and normal population.

Full description

This study investigates the difference of volatile organic compound in the exhaled breath of the patients with GI bleeding and normal population. We aimed to find out the biomarkers for GI bleeding.

Enrollment: 60 estimated patients

Sex: All

Ages: 20 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Adults aged between 20 and 80
• Low possibility of gastrointestinal bleeding was proven by esophagogastroduodenoscopy and colonoscopy which were performed within 1 year.
• NSAID non-user (within 1 months before the date of inclusion)

Exclusion criteria

• Diagnosis of malignancy diagnosed within 5 years
• Past medical history of chronic liver disease, chronic kidney disease, chronic lung disease, chronic bronchial disease, asthma
• Surgical history of any kind of gastrectomy
• Surgical history of any kind of lung resection which could impact the patient's lung function.

Trial design

60 participants in 2 patient groups

Normal control

Description:

Normal population with low prevalence of gastrointestinal bleeding who underwent EGD and CFS which revealed no abnormal finding.

Treatment:

Diagnostic Test: Collection of exhaled breath

Patients with GI bleeding

Description:

Patients who visited emergency room and were highly suspected to have recent or active upper GI bleeding and scheduled for upper GI endoscopy.

Treatment:

Diagnostic Test: Collection of exhaled breath