Volatile Versus Propofol Anesthesia in OPCAB

Samsung Medical Center

Status: Completed

Conditions: Off Pump Coronary Artery Bypass Graft

Treatments: Drug: Isoflurane

Study type: Observational

Funder types: Other

Identifiers

NCT02222142

2013-09-127

Details and patient eligibility

About

Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode. The investigators retrospectively evaluated the cardioprotective and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB.

Full description

Several experimental and clinical researches have suggested that volatile anesthetics may reduce mortality in cardiac surgery owing to its preconditioning induced cardioprotective effect. Off-pump coronary artery bypass graft (OPCAB) surgery still requires cardioprotective strategies due to coronary hypoperfusion during anastomosis. The aim of this study was to evaluate the possible cardioprotective effect and clinical outcomes of propofol versus isoflurane anesthesia in patients undergoing OPCAB using propensity matching.

Enrollment: 1,080 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• OPCAB

Exclusion criteria

• On pump conversion

Trial design

1,080 participants in 2 patient groups

Isoflurane group

Description:

Isoflurane inhalational anesthesia during OPCAB

Treatment:

Drug: Isoflurane

Propofol group

Description:

Total intravenous anesthesia with propofol during OPCAB