Volumetric Bone Mineral Density and it's Relationship With Osteoporotic Fractures in Parkinson's Disease (DOPPA)

Centre Hospitalier Régional d'Orléans

Status: Completed

Conditions: Idiopathic Parkinson's Disease

Treatments: Other: High resolution peripheral scanner (HRpQCT).

Study type: Interventional

Funder types: Other

Identifiers

NCT03095690

CHRO-2015-05

Details and patient eligibility

About

Idiopathic Parkinson's disease (IPD) is the second most frequent neurodegenerative disease. Its association with osteroporosis and fragility fracture is now clearly demonstrated, but the determinants of this osteoporosis are yet to be explained. Our aim was to study factors associated with volumetric bone mineral density (vBMD) and bone microstructure at the tibia and radius in IPD.

Enrollment: 90 patients

Sex: All

Ages: 35 to 85 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients with idiopathic Parkinson's disease according to the criteria of the UKPDBB.
• Parkinson's disease of moderate severity (Index HOEHN and Yahr <5)
• Patient can respond to questionnaires, with or without help

Exclusion criteria

• Patients with active psychiatric illness preventing the realization of examinations
• Severe Parkinson's disease (Index HOEHN and Yahr ≥5 )
• Heavy-morbidity including heart failure NYHA> 3 or chronic respiratory failure, terminal or severe renal impairment known dialyzed
• Pregnancy

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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90 participants in 1 patient group

Idiopathic Parkinson's Disease patients

Other group

Description:

High resolution peripheral scanner (HRpQCT).

Treatment:

Other: High resolution peripheral scanner (HRpQCT).