Von Willebrand Factor As a Biological Sensor of Blood Flow in Percutaneous Cardiac Procedure (WiTAVi)

University Hospital, Lille

Status: Unknown

Conditions: Heart Failure; Aortic Stenosis

Treatments: Device: cardiac devices

Study type: Observational

Funder types: Other

Identifiers

NCT02628509

NI_59

Details and patient eligibility

About

The WITAVI study was designed to explore the kinetic and associated outcome of Von Willebrand Factor-multimerizaton defects associated with devices in cardiovascular diseases.

Full description

This study was designed to understand the Von Willebrand Factor (VWF) abnormalities observed in association with implantation of different devices in cardiovascular diseases (percutaneous valve replacement and circulatory support devices).

The main objective of the study was to describe the time-course of VWF abnormalities onset/offset during implantation of devices in cardiovascular diseases.

Adult patients > 18 years who need a CF-LVAD or trans-aortic valve implantation are included in this cohort; Blood samples are obtained just before procedures

Enrollment: 500 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients > 18 years who need a mechanical circulatory support due to advanced heart failure or undergoing trans-aortic-valve-replacement to treat aortic stenosis.
• Informed consent of the patient or support person in case of disability at baseline (patient intubated and ventilated)

Exclusion criteria

• Patient with a known severe bleeding disorder
• Patient refusal or environment
• Minor patients
• Pregnant women

Trial design

500 participants in 1 patient group

cardiac devices

Description:

patients receiving mechanical circulatory support patients undergoing transaortic valve replacement

Treatment:

Device: cardiac devices