Walking Training Improves Thyroid and Cardiometabolic Markers in Postmenopausal Obesity

Wissal Abassi

Status: Completed

Conditions: Cardiometabolic Risk Factors; Thyroid Hormones

Treatments: Other: Moderate intensity intermittent walking training

Study type: Interventional

Funder types: Other

Identifiers

NCT06793345

Training and thyroid function

Details and patient eligibility

About

The goal of this clinical trial is to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. The main question it aims to answer is:

Does MIWT enhance thyroid function and reduce cardiometabolic risk factors in this population? Researchers will compare MIWT (designed to MIWT group) to non-training intervention (designed to control group) to see if the training program works to improve thyroid function and cardiometabolic risk factors.

Participants in MIWT group will: perform a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions).

Participants in control group will : not perform any physical training and maintain their usual daily activities.

Full description

This study aimed to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. Thirty-six obese postmenopausal women (BMI≥30 kg.m-2, aged 50-60 yrs.) were randomized to either a moderate-intensity intermittent walking training (MIWT) group (n=18) or control group (CG, n=18). Participants performed a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone (TSH) and thyroxine free (FT4)), lipid profile (triglycerides (TRG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC) and low-density lipoprotein cholesterol(LDLC)), blood pressure (systolic and diastolic blood pressure) and aerobic fitness (6MWT) were determined before and after the MIWT.

Enrollment: 36 patients

Sex: Female

Ages: 50 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Body mass index≥ 30 kg.m-2.
• Age between 50 and 60.
• Amenorrhea for >12 months.
• Stable eating habits.

Exclusion criteria

• Chronic diseases.
• Medical contraindications to physical activity.
• Hormone replacement therapy.

Trial design

Primary purpose: Health Services Research

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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36 participants in 2 patient groups

MIWT group

Experimental group

Description:

The MIWT group received moderate intensity intermittent walking training four times per week for 10 weeks.

Treatment:

Other: Moderate intensity intermittent walking training

Control group

No Intervention group

Description:

The control group received no intervention for 10 weeks.