Walking Training in Peripheral Artery Disease (GrEnADa Sub-study)

Catholic University (KU) of Leuven

Status: Withdrawn

Conditions: Peripheral Artery Disease; Intermittent Claudication

Treatments: Other: Stretching exercise group; Other: Walking training group

Study type: Interventional

Funder types: Other

Identifiers

NCT02879019

150716_GrenSub

Details and patient eligibility

About

Whereas the efficacy of exercise interventions has been abundantly proven in male with peripheral artery disease (PAD), it remains to be determined whether these interventions are effective in women. The aim of this randomized controlled trial which will be performed with 34 PAD women will be to investigating the effects of 12 weeks of supervised walking on functional capacity and cardiovascular function and regulation at rest and during exercise.

Sex: Female

Ages: 50 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• aankle-brachial index (ABI) ≤ 0.9 in one or two legs
• fontaine stage II of PAD
• body mass index <35 kg/m2
• resting systolic blood pressure (BP) <160 mmHg and diastolic BP <105 mmHg
• ability to walk at least 2min at 3.2 km/h
• ability to undertake an incremental treadmill test
• decrease of at least 15% in ABI after a maximal treadmill test
• not currently engaging in any regular exercise program

Exclusion criteria

• exercise induced signs of myocardial ischemia or complex ventricular arrhythmias
• cardiovascular autonomic neuropathy
• use of beta-blocker, nondihydropyridine calcium antagonists or insulin and hormone replacement therapy.

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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0 participants in 2 patient groups

Stretching exercise group

Sham Comparator group

Description:

Patients will receive two session per week of stretching classes.

Treatment:

Other: Stretching exercise group

Walking training group

Experimental group

Description:

Patients will perform two walking sessions per week.

Treatment:

Other: Walking training group