Walnut Consumption, Endothelial Function, and Biomarkers

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Mass General Brigham

Status

Completed

Conditions

Coronary Heart Disease
Type 2 Diabetes

Treatments

Other: Once ounce per day of walnuts

Study type

Interventional

Funder types

Other

Identifiers

NCT01884363
2013P000803

Details and patient eligibility

About

This study will examine whether a twelve-week intervention with one ounce (28 g) per day of walnuts improves endothelial function measured non-invasively using finger probe (EndoPat-2000) in people with coronary heart disease or type 2 diabetes.

Enrollment

26 patients

Sex

All

Ages

30+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

* Age 30+ years * Prevalent coronary artery disease * Prevalent type 2 diabetes

Exclusion criteria

* Current eating disorder * Pregnant or lactating women * Allergy to walnuts or other nuts * Inability to provide informed consent or blood samples * History or prevalent diagnosis of cancer, asthma, kidney insufficiency, stroke, seizures, allergic disorders, or congestive heart failure * Diagnosis of coronary heart disease or diabetes \< 1 year prior to enrollment * Intention to move out of greater Boston area within one year * Current use of walnuts for more than 2 ounces per day * Bleeding disorder * Treatment with blood thinning drugs (i.e. warfarin, clopidogrel) * Major surgical operation 3 months before or after screening * Organ transplantation * Current participation in another trial or plan to do so during the study * Use of vasodilators such as nitroglycerin * Inability to give informed consent * Inability to travel to the study center at Brigham and Women's Hospital

Trial design

26 participants in 2 patient groups

Walnuts
Experimental group
Description:
This group will receive one ounce of walnuts per day
Treatment:
Other: Once ounce per day of walnuts
Usual diet (no walnuts)
No Intervention group
Description:
Control group (does not receive walnuts in the diet)

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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