Warfarin and Coronary Calcification Project (WACC)

W

Walter Reed Army Medical Center

Status

Completed

Conditions

Coronary Calcification

Study type

Observational

Funder types

Other U.S. Federal agency

Identifiers

NCT00868712
WU# 04-12020

Details and patient eligibility

About

The purpose of the study is to assess whether the use of warfarin, a commonly used anticoagulation drug, is associated with increased amounts of coronary artery calcification. Studies in animals and preliminary but small retrospective studies in humans have suggested a possible link to increased tissue calcification with use of this drug. The researchers will investigate this by assessing the amount of calcification seen in the coronary arteries using a specialized computed tomography (CT) scan (electron-beam CT) and assessing to see if the amount is influenced by the amount of time a patient has been taking warfarin. The researchers will exclude patients with known coronary artery disease, chronic kidney disease or hyperparathyroidism.

Enrollment

70 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Age 18 years of age or older
  • Patients referred to begin or already treated with warfarin anticoagulation therapy.

Exclusion criteria

  • Known prior myocardial infarction or coronary heart disease
  • History of advanced chronic kidney disease manifested by serum creatinine>2 or calculated glomerular filtration rate (GFR)<30
  • History of hyperparathyroidism
  • Current hypercalcemia
  • Current hyperphosphatemia
  • Uncertain duration of warfarin therapy
  • Lack of records documenting international normalized ratio (INR) during therapy

Trial design

70 participants in 3 patient groups

1
Description:
Warfarin use < 6 months
2
Description:
Warfarin use 6-24 months
3
Description:
Warfarin use >24 months

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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