ClinicalTrials.Veeva

Menu

Warrior CARE: Naturalistic Observation and Harm Reduction (NOC)

Wayne State University logo

Wayne State University

Status

Withdrawn

Conditions

Post Traumatic Stress Disorder
Cannabis Use
Suicide

Treatments

Behavioral: Reduce THC Use

Study type

Interventional

Funder types

Other

Identifiers

NCT05386862
Warrior CARE: NOC

Details and patient eligibility

About

This study is looking at therapeutic potential of reducing Tetrahydrocannabinol (THC) levels in regular cannabis smokers using contingency management (CM) intervention in a U.S. veteran population with post-traumatic stress disorder (PTSD).

Full description

In this trial, the investigators will recruit veterans with post-traumatic stress disorder (PTSD) who report using cannabis. Veterans will be assigned (via participant self-selection) into either a naturalistic group that will be followed as the participants continue to use cannabis as they normally do (observation only), or into a "THC (tetrahydrocannabinol) reduction group" in which veterans are asked to switch from their typical cannabis product to using a lower THC/higher Cannabidiol (CBD) product; adherence to this switch will be incentivized using a behavioral intervention called contingency management (CM).

Sex

All

Ages

19 to 69 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • able to provide informed consent, IQ Score >80,
  • served in branch of the US armed forces, report using cannabis,
  • report using cannabis (at least 4x/month)
  • test positive for THC in urine drug screen,
  • meet DSM-5 criteria for PTSD w/ Sx of at least 6 months duration

Exclusion criteria

  • urine drug screen positive for any other drugs
  • any clinically significant medical problems,
  • any current or past serious psychotic or bipolar disorder diagnosis as determined by SCID-5
  • at immediate high risk for suicide based on the C-SSRS
  • current SUD other than Nicotine Use Disorder, Alcohol (mild or moderate) and Cannabis Use Disorder
  • seeking treatment for Cannabis Use Disorder

Trial design

Primary purpose

Treatment

Allocation

Non-Randomized

Interventional model

Parallel Assignment

Masking

None (Open label)

0 participants in 2 patient groups

Naturalistic Group
No Intervention group
Description:
This group will followed as they follow their naturalistic cannabis use.
THC Reduction Group
Experimental group
Description:
This group will be asked to reduce the THC content and increase CBD content of their cannabis products to study the effect of PTSD symptom severity.
Treatment:
Behavioral: Reduce THC Use

Trial contacts and locations

1

Loading...

Central trial contact

Klevis Study Coordinator, MS; Reshma Research Assistant, BS

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2024 Veeva Systems