Water- and Salt-homeostasis in Healthy Humans, and in Patients With Heart- or Lung Disease

Kolding Sygehus

Status: Unknown

Conditions: Ischemic Heart Disease; Healthy Volunteers; Heart Failure; Pulmonary Hypertension; Aortic Stenosis

Treatments: Procedure: Revascularisation in Acute Coronary Syndrome; Procedure: Revascularisation in chronic stable angina pectoris; Procedure: Aortic valve replacement; Drug: Pharmacologic and mechanical heart failure treatment

Study type: Observational

Funder types: Other

Identifiers

NCT00830726

S-20080141

Details and patient eligibility

About

The purpose of the study is to determine whether the excretion of renal water- and salt-channels in the urine reflects the handling of water and salt in the kidneys, and whether the excretion can be used to monitor and/or predict the effects of treatment of certain heart or lung diseases.

Full description

The purpose of the study is to determine whether the excretion of renal water- and salt-channels (Aquaporin-2 and Epithelial Sodium Channels) in the urine accurately reflects the handling of water and salt in the distal tubules af the kidneys, and whether quantification of these channels in the urine is useful to monitor and/or predict the effects of pharmacologic or surgical treatment of Heart Failure and heart failure-related diseases (Aortic stenosis, acute and chronic ischemic heart disease or pulmonary hypertension)

Enrollment: 150 estimated patients

Sex: All

Ages: 30 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Symptomatic heart failure
• Severe valvular aortic stenosis
• Acute Coronary Syndrome
• Medically refractory chronic angina pectoris or pulmonary hypertension with preserved left ventricular function

Exclusion criteria

• Pregnancy
• Drug abuse
• Malignant disease
• Significant disease of other organs including endocrine diseases

Trial design

150 participants in 6 patient groups

1

Description:

Healthy volunteers

2

Description:

Patients with symptomatic heart failure and EF \< 40%

Treatment:

Drug: Pharmacologic and mechanical heart failure treatment

3

Description:

Patients with symptomatic aortic valve stenosis

Treatment:

Procedure: Aortic valve replacement

4

Description:

Patients with Acute Coronary syndromes prior to surgical intervention

Treatment:

Procedure: Revascularisation in Acute Coronary Syndrome

5

Description:

Patients with refractory stable angina requiring surgical intervention.

Treatment:

Procedure: Revascularisation in chronic stable angina pectoris

6

Description:

Patients with pulmonary hypertension and preserved systolic left ventricular function.