Water and the Gastropressor Response - Tachyphylaxis

Satish R. Raj

Status: Active, not recruiting

Conditions: Orthostatic Hypotension

Treatments: Other: water tiny dose; Other: water high dose

Study type: Interventional

Funder types: Other

Identifiers

NCT00580996

Vanderbilt Discovery

060547

Details and patient eligibility

About

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier.

Full description

We are studying the effects of oral water ingestion in patients with orthostatic hypotension. This has been termed the Gastropressor Response. In this study, we are testing the null hypothesis that the blood pressure increase with oral water ingestion will not be diminished if a full prior water dose is given a few hours earlier. In this 2 day study, subjects will be asked to drink with 1 oz or 16 oz of water in the morning followed a few hours later by 16 oz water while the blood pressure is monitored. On the 2nd day, the other dose of water will be given to start, with 16 oz again as the second dose.

Enrollment: 20 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• orthostatic hypotension (fall in BP>20/10 mmHg)
• pressor response to water in other studies
• Age 18-80 years

Exclusion criteria

• pregnancy

Trial design

Primary purpose: Other

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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20 participants in 2 patient groups

1

Experimental group

Description:

16 oz water in AM

Treatment:

Other: water high dose

2

Active Comparator group

Description:

water 1 oz in AM

Treatment:

Other: water tiny dose