Water Intake and Glycemic Response : Preliminary Study

Nutrifood Research Center, Jakarta, Indonesia

Status: Unknown

Conditions: Healthy

Treatments: Other: White Bread with 250 ml water; Other: White Bread and 700 ml water; Other: White Bread with 125 ml water (twice); Other: Glucose Ref and 450 ml water; Other: Glucose Ref - Std

Study type: Interventional

Funder types: Industry

Identifiers

NCT02625363

Nutrifood

Details and patient eligibility

About

Glycemic index concept is widely used to determine impact of a food to blood glucose. Several studies showed that water content and intake after meal may influence glycemic response of the meal and thus have an effect on the result of GI measurement. Currently these studies found conflicting results. Therefore, this study aims to determine whether water intake, specifically after meal, may influence the glycemic response and glycemic index value of the meal.

Full description

Glycemic index methods are performed according to Food and Agricultural Organization/WHO recommendations.

Enrollment: 10 estimated patients

Sex: All

Ages: 20 to 40 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age between 20-40 years
• fasting blood glucose 70-99 mg/dL
• Indonesians

Exclusion criteria

• having diabetes
• smoking
• if women, pregnant or lactating
• being allergic to food used in this study
• having gastrointestinal disturbance
• in regular medication
• refusal to sign the consent form

Trial design

Primary purpose: Basic Science

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Single Blind

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10 participants in 5 patient groups

Glucose Ref - Std

Experimental group

Description:

250 ml glucose solution with 50 gram available carbohydrate per serving, used as reference

Treatment:

Other: Glucose Ref - Std

Glucose Ref and 450 ml water

Experimental group

Description:

250 ml glucose solution with 50 gram available carbohydrate per serving. Sample was consumed with additional water intake @150 ml at 45, 75, and 105 minutes after meal consumption

Treatment:

Other: Glucose Ref and 450 ml water

White Bread with 250 ml water

Experimental group

Description:

White bread with 50 gram available carbohydrate was consumed with 250 ml water immediately after meal consumption

Treatment:

Other: White Bread with 250 ml water

White Bread and 700 ml water

Experimental group

Description:

White bread with 50 gram available carbohydrate was consumed with 250 ml water immediately after meal consumption. Moreover, subjects given additional water intake @150 ml at 45, 75, and 105 minutes after meal consumption

Treatment:

Other: White Bread and 700 ml water

White Bread with 125 ml water (twice)

Experimental group

Description:

Sample consumed with 125 ml water immediately after meal consumption, and additional 125 ml water after 60 minutes

Treatment:

Other: White Bread with 125 ml water (twice)