Water Load Test Value for Hyponatremia (WATERLINE)

European Georges Pompidou Hospital

Status

Completed

Conditions

Hyponatremia

SIAD - Syndrome of Inappropriate Antidiuresis

Treatments

Procedure: Acute water load test

Study type

Observational

Funder types

Other

Identifiers

NCT04256499

WATERLINE

Details and patient eligibility

About

Acute water load test has been using to diagnose renal ability to excrete water for decades. Latest recommendations for the diagnosis of hyponatremia do not recommend performing such a test. The investigators aim at, retrospectively, study the value of acute water load test in patients suffering from a syndrome of inappropriate antidiuresis.

Enrollment

150 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

≥ 18 years old at the time of the test
affiliated to a social insurance system
water load test performed at the Renal and Metabolic Diseases Unit of the European George Pompidou Hospital, AP-HP, Paris, France
between 01/01/2001 and 12/31/2019

Exclusion criteria

hypernatremia and/or polyuria-polydipsia (diabetes insipidus)
hyponatremia due to a tea and toast syndrome and/or a beer potomania
hyponatremia due to a high (or normal) osmolality related to diabetes mellitus, hyperproteinemia and/or intoxication
chronic kidney disease with an estimated glomerular filtration rate (eGFR) by the MDRD formula <60 mL/min/1.73m2
hyponatremia related to thiazides
hyponatremia related to an hypovolemic status
syndrome of inappropriate antidiuresis related to an endocrine disorder (such as hypothyroidism or adrenal insufficiency)