We Analyse Metabolites in Dried Blood Spots From Newborns That Later in Life Developed an Eating Disorder.

Karolinska Institute

Status: Active, not recruiting

Conditions: Eating Disorders

Study type: Observational

Funder types: Other

Identifiers

NCT07016334

Analysis of blood spots in ED

Details and patient eligibility

About

Anorexia nervosa (AN) and bulimia nervosa (BN) are serious eating disorders (EDs) with significant morbidity and mortality. Genetic studies have shown associations between EDs and metabolic traits, and longitudinal studies indicate distinct weight trajectories in children who later develop AN or BN, suggesting early involvement of metabolic factors. Biological studies also reveal differences in immune and neurotrophic markers in individuals with EDs compared to controls. Intriguingly, metabolites measured in neonatal blood could serve as very early markers of ED risk, unconfounded by state or scar factors related to prolonged starvation.

Here the investigators propose to comprehensively analyze neonatal biomarkers (metabolic, immune, and neurotrophic), epidemiological factors, and genetics to understand ED risk and develop risk prediction models

Enrollment: 3,000 patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• in PKU-register with or withou life-time diagnosis of anorexia or bulimi nervosa

Exclusion criteria

• not in PKU register

Trial design

3,000 participants in 3 patient groups

Anorexia nervosa

Description:

Diagnosed (life-time) with anorexia nervosa

Bulimia nervosa

Description:

Diagnosed (life-time) with bulimia nervosa

Controls

Description:

Never diagnosed with anorexia or bulimia nervosa