Weaning From Mechanical Ventilation Guided by Lung Ultrasound (Brazilian WEANLUS) (WEANLUS-BR)

D'Or Institute for Research and Education

Status and phase: Unknown; Phase 3

Conditions: Acute Respiratory Failure

Treatments: Other: weaning guided by LUS (lung ultrasound)

Study type: Interventional

Funder types: Other

Identifiers

NCT01966861

IDOR-03-2013

Details and patient eligibility

About

The present study aims to evaluate the impact of a weaning strategy based on identification of early signs of respiratory distress by lung ultrasound and the consequent implementation of a "clinical optimization" protocol as compared to usual care.

Enrollment: 300 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Mechanically ventilated >48h

Exclusion criteria

• Moderate/Severe COPD
• Spinal cord lesion
• Neuromuscular disease (previous)
• Lung fibrosis
• Tracheostomy
• Heart failure (EF<50%)
• Lung/pleural cancer
• inadequate "window"for LUS

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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300 participants in 2 patient groups

usual care

No Intervention group

Description:

Weaning as protcolised by the units' daily practice (SBT)

Weaning guided by lung ultrasound

Experimental group

Description:

Predictive early signs of respiratory distress are assessed by lung ultrasound and if found will trigger protocolised intervention (eg- fluid balance,diuretics, thoracocentesis)

Treatment:

Other: weaning guided by LUS (lung ultrasound)