Wearable Sensors for Quantitative Assessment of Motor Impairment in Huntington's Disease Huntington's Disease

BioSensics

Status: Unknown

Conditions: Huntington Disease

Treatments: Other: HD Wear

Study type: Observational

Funder types: Other; Industry

Identifiers

NCT03599076

1R44NS103648-01

Details and patient eligibility

About

The principal means of measuring motor impairment in Huntington disease (HD) is the Unified Huntington's Disease Rating Scale (UHDRS) total motor score, which is subjective, categorical, requires significant training to administer correctly, and only captures impairments in clinic. In this Direct to Phase II SBIR we will develop a wearable sensor system for objective, sensitive, and continuous assessment of Huntington's chorea during activities of daily living. The developed technology could be used clinically to detect changes in motor function in response to medications, or could be used scientifically to expedite and reduce the cost of early stage pharmaceutical clinical trials.

Enrollment: 50 estimated patients

Sex: All

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• CAG expansion ≥ 36

Exclusion criteria

• N/A

Trial design

50 participants in 3 patient groups

Manifest HD

Treatment:

Other: HD Wear

Premanifest HD

Treatment:

Other: HD Wear

Control

Treatment:

Other: HD Wear