Weight Changes During and After Pregnancy in Women With Gestational Diabetes

Vanderbilt University

Status: Completed

Conditions: Gestational Diabetes Mellitus

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT02388958

140295

P30DK092986 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

Gestational diabetes mellitus (GDM) is associated with short-term and long-term complications for infants and mothers. The management of GDM during pregnancy focuses on reducing risks to the infant associated with hyperglycemia. The postpartum management of GDM focuses on reducing maternal risk of developing type 2 diabetes (T2DM). A diagnosis of GDM identifies up to 31% of parous women who will eventually develop T2DM and approximately 50% of women diagnosed with GDM will develop T2DM in the first 5 years postpartum. The perceived risk of developing short-term and/or long-term complications of GDM may influence women's likelihood of engaging in diet modification, the mainstay of treatment of GDM, both during and after pregnancy. If sustained after delivery, diet modifications introduced as treatment for GDM could affect maternal weight changes during and after pregnancy, which could in turn affect T2DM risk. It is unknown if and how women with GDM differ in their perceived risk of developing T2DM, dietary choices, or weight gain (and retention) during versus after pregnancy. Therefore, the project proposed in this application seeks to (1) characterize the perceived risk of developing T2DM among women with GDM during and after pregnancy, (2) characterize dietary choices of women with GDM during and after pregnancy, and (3) characterize weight changes of women with GDM during and after pregnancy as compared to women without GDM.

Enrollment: 89 patients

Sex: Female

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion and exclusion criteria

Inclusion Criteria for women with GDM:

• Patient is currently pregnant with a singleton pregnancy.
• Laboratory confirmed diagnosis of GDM between weeks 24-28 gestation.
• Patient is receiving routine prenatal care at Vanderbilt University Medical Center.

Inclusion Criteria for women without GDM:

• Patient is currently pregnant with a singleton pregnancy.
• Patient does not have GDM based on non-fasting and/or fasting GTT results.
• Patient is receiving routine prenatal care at Vanderbilt University Medical Center.

Exclusion Criteria for both cohorts:

• Diagnosis of type 1 or type 2 diabetes prior to pregnancy.
• Diagnosis of GDM prior to 20 weeks gestation.
• Patient does not speak English.

Trial design

89 participants in 2 patient groups

Women with GDM

Women without GDM