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About
The purpose of this study is to assess the effectiveness of two different reduced calorie diets that have different combinations of carbohydrate, fat, and protein content in 2 groups of study participants: insulin sensitive participants and insulin resistant participants. The hypothesis of the study is that people with high and low levels of insulin resistance may respond differently to different diet compositions in a real-world environment using meals that are commonly available.
Enrollment
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Inclusion criteria
Exclusion criteria
Pregnant or lactating.
Must not currently be part of a structured weight loss program
Taking a medication for diabetes (such as insulin, metformin, glyburide, glipizide, Byetta, pioglitazone, or rosiglitazone) or a medication such as systemic glucocorticoids that are known to affect blood sugar or blood insulin.
Beck Depression Inventory (BDI Score >19 and/or positively endorses the suicide question on the BDI-II)
Taking any chronic medication that has not had a stable dose for 1 month or longer.
Diabetes mellitus defined as a fasting glucose ≥ 126 mg/dL on screening.
Taking medications or dietary supplements that cause weight gain or weight loss (eg. antipsychotics (Seroquel, Zyprexa, and Risperdal) and/or anorectics).
Clinically significant laboratory abnormalities at the opinion of the investigators.
History of Bariatric Surgery
A history of:
Primary purpose
Allocation
Interventional model
Masking
100 participants in 2 patient groups
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Data sourced from clinicaltrials.gov
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