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Weight Loss Management in Endometrial Cancer Survivors (ECS Weight)

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University of Kansas

Status

Enrolling

Conditions

Endometrial Cancer Survivors
Early Stage Endometrial Cancer
Weight Management

Treatments

Behavioral: Weight loss without pharmacotherapy
Behavioral: Weight loss with pharmacotherapy

Study type

Observational

Funder types

Other

Identifiers

NCT06877572
STUDY00160821

Details and patient eligibility

About

This study is being done to understand how oncologists can engage a multidisciplinary team to help endometrial cancer survivors with obesity to engage in a weight management program and potentially start a weight loss medication. Obesity often impacts the future health and longevity of early-stage endometrial cancer survivors more than their cancer diagnosis.

Patients will be referred to the KUMC OB/Gyn weight management clinic to discuss weight management options.

  • If patients decide to use medications for weight loss, then the study will collect data from their chart that is recorded as part of routine monitoring for patients on weight loss medications.
  • If patients decide not to use any medications, the study will monitor physical exam and lab data collected as part of their routine medical care.

The study will also try to understand reasons why patients did or did not start using a weight loss medication.

Enrollment

50 estimated patients

Sex

Female

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • ≥18 years old
  • ECOG 0-2
  • BMI ≥ 30kg/m2
  • Completed surgical staging with no evidence of residual disease
  • Endometrioid endometrial adenocarcinoma, p53 wild type
  • Stage 1
  • Undergoing active surveillance +/- brachytherapy

Exclusion criteria

  • Unable to participate in behavior weight loss
  • Stroke, heart attack, end stage liver disease, or end stage kidney disease during the last 6 months.
  • Currently on a GLP-1 agonist
  • Currently on insulin

Trial design

50 participants in 1 patient group

Endometrial cancer survivors with weight management
Description:
Survivors of low-risk early-stage endometrial cancer up to 36 months post primary treatment with body mass index (BMI) ≥30 kg/m2
Treatment:
Behavioral: Weight loss with pharmacotherapy
Behavioral: Weight loss without pharmacotherapy

Trial contacts and locations

1

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Central trial contact

Co-investigator; Principal Investigator

Data sourced from clinicaltrials.gov

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