Weight Loss Via Bariatric Surgery and Lifestyle Modification

King Saud University

Status: Completed

Conditions: Weight Loss; Obesity

Treatments: Other: Control; Procedure: Sleeve gastrectomy; Dietary Supplement: Lifestyle intervention

Study type: Observational

Funder types: Other

Identifiers

NCT05775172

BSvsLS

Details and patient eligibility

About

Gastric myoelectric, inflammatory, and hormonal responses, body compositional, energy expenditure, and metabolic changes during the development of obesity and the weight loss process are underinvestigated. This project studied the myoelectrical inflammatory and hormonal responses of the stomach, in addition to energy expenditure and body composition changes during weight loss via bariatric surgery and lifestyle intervention.

Full description

Gastric myoelectric, inflammatory, and hormonal responses, body compositional, energy expenditure, and metabolic changes during the development of obesity and the weight loss process are underinvestigated. This project studied the myoelectrical, inflammatory, and hormonal responses of the stomach, in addition to energy expenditure and body composition changes during weight loss via bariatric surgery and lifestyle intervention.

Methods: We recruited 79 participants who were assigned to three groups: bariatric surgery (BS group n=27), lifestyle intervention (LS group, n=22), and waitlist control (C group n=30). For all participants, electrogastrography, inflammatory cytokines, gastric hormones analysis, body composition analysis, energy expenditure, and dietary assessment were done at baseline and at 6 months.

Enrollment: 79 patients

Sex: All

Ages: 18 to 60 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• BMI > 35 kg/m2,
• Being free of any acute medical condition, inflammatory conditions, malignancy, or psychiatric disorders

Exclusion criteria

• Taking weight-losing pharmacotherapy
• Who underwent previous bariatric surgery

Trial design

79 participants in 3 patient groups

Waitlist control

Description:

Waitlist control (C group n=30) did not achieve any significant weight loss and did not follow lifestyle intervention

Treatment:

Other: Control

Lifestyle intervention

Description:

Lifestyle intervention (LS group, n=22) follows multimodal lifestyle intervention in form of 500-100 kcal deficit , gradual physical activity and some behavioral modifications

Treatment:

Dietary Supplement: Lifestyle intervention

Bariatric surgery

Description:

Bariatric surgery (BS group n=27) undergoes laparoscopic sleeve gastrectomy

Treatment:

Procedure: Sleeve gastrectomy