Weissella Cibaria JW15 Consumption and NK Cell Activity

Yonsei University

Status: Completed

Conditions: Immune Function

Treatments: Dietary Supplement: Placebo; Dietary Supplement: Probiotic

Study type: Interventional

Funder types: Other

Identifiers

NCT03209635

AI_probiotic_NK

Details and patient eligibility

About

A The aim of this study was to investigate the impact of consuming Weissella cibaria (W. cibaria) JW15 supplementation isolated from Kimchi, Korea traditional fermented food, on natural killer (NK) cell activity and circulating levels of cytokines and immunoglobulin (Ig).

Full description

A randomized, double-blinded, placebo-controlled study was conducted on 100 nondiabetic subjects. Over an eight-week testing period, the probiotic group consumed 4 capsules (300 mg/capsule) containing 1 x 10^10 colony-forming units (cfu) of W. cibaria JW15 each day, whereas the placebo group consumed the same product without a probiotic.

Enrollment: 100 patients

Sex: All

Ages: 20 to 70 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Nondiabetic (fasting serum glucose concentration < 126 mg/dL)
• Subjects with 4,000-8,000 leukocyte counts

Exclusion criteria

• Constant consumption of any probiotic products
• Taking medicine related to inflammation within one month before screening
• Allergy to probiotics
• Lactose intolerance
• Diabetes
• History/presence of significant metabolic disease
• Acute or chronic disease requiring treatment
• Taking any medications

Trial design

Primary purpose: Supportive Care

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: Double Blind

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100 participants in 2 patient groups, including a placebo group

Placebo

Placebo Comparator group

Description:

4 capsules (300 mg/capsule) containing 52% crystalline cellulose and 46% lactose in identical-looking with test product

Treatment:

Dietary Supplement: Placebo

Probiotic

Experimental group

Description:

4 capsules (300 mg/capsule) containing each capsule 1.0 x 10\^10 colony-forming units (cfu) of Weissella cibaria JW15, twice a day

Treatment:

Dietary Supplement: Probiotic