Wellness, Intervention Strategies and HIV Care (WISH)

University of California San Francisco (UCSF)

Status: Enrolling

Conditions: HIV; Substance Use Disorder (SUD)

Treatments: Behavioral: Movie Night Club - Attention and Time Matched Control; Behavioral: Wellness, Intervention Strategies and HIV Care (WISH)

Study type: Interventional

Funder types: Other; NIH

Identifiers

NCT07069374

K01DA056306 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

This is a pilot trial designed to assess the feasibility and acceptability of an intervention aimed at improving adherence to antiretroviral therapy (ART), viral suppression, and engagement in HIV care. The intervention will address behavioral coping strategies, HIV care engagement behaviors, and substance use management.

Enrollment: 50 estimated patients

Sex: Female

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Participants must:

• Be at least 18 years of age

• Self-report biological characteristics consistent with the population under study

• Be HIV-positive

• Report use of at least one of the following substances in the last 90 days:

  • Cannabis
  • Methamphetamine
  • Cocaine/crack
  • Cocaine
  • Heroin
  • Non-prescribed opioids (e.g., fentanyl, morphine)
  • Ecstasy
  • Phencyclidine (PCP)
  • Psychedelics (e.g., Lysergic acid diethylamide, mescaline, ketamine)
  • Poppers (alkyl nitrites)
  • Non-prescribed benzodiazepines (e.g., Valium, Xanax, Klonopin, Librium)
  • Barbiturates

• Be English-speaking

• Be able and willing to provide informed consent

Exclusion criteria

• Evidence of severe cognitive impairment or active psychosis that may impede ability to provide fully informed consent, determined by the research assistants and clinical supervisor(s)
• The research staff are trained on guidelines for identifying participants who exhibit signs of inability to meaningfully participate or provide consent due to mental illness or impairment

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: None (Open label)

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50 participants in 2 patient groups, including a placebo group

Intervention Arm

Experimental group

Description:

Participants in this arm will attend a structured, group-based behavioral support program consisting of five weekly sessions. The intervention is designed for individuals living with HIV who use substances. It focuses on strategies for managing stress, reducing barriers to care, and improving engagement in HIV-related health services and overall wellness.

Treatment:

Behavioral: Wellness, Intervention Strategies and HIV Care (WISH)

Control Arm

Placebo Comparator group

Description:

Participants in this arm will attend five weekly group-based sessions where non-intervention-related movies are shown. This condition is intended to control for time and group exposure without delivering active behavioral content related to the study outcomes.

Treatment:

Behavioral: Movie Night Club - Attention and Time Matched Control