Westlake Nutrition and Brain Health Study (WEBRAIN)

Westlake University

Status: Active, not recruiting

Conditions: Aging

Treatments: Other: Whole grain breakfast; Other: Refine grain breakfast

Study type: Interventional

Funder types: Other

Identifiers

NCT04135066

20190901ZJS0010

Details and patient eligibility

About

Westlake Nutrition and Brain Study (WEBRAIN) is a sub-study of the Guangzhou Nutrition and Health Study, a prospective cohort among participants living in Guangzhou city. The aim of the WEBRAIN is to investigate the relationship between diet, gut microbiome and brain health in the elderly individuals via deep phenotyping the participants including continuous blood glucose monitoring for standard test meal, objective physical activity measurement and brain magnetic resonance imaging.

Full description

The gut-brain axis has been considered a possible cause of neurodegenerative diseases via various mechanisms, and diet/nutrition has been linked to both gut and brain health. However, majority of related evidence derived from animal models or human study of small scale.

In the WEBRAIN, we aim to investigate the relationship between diet, gut microbiome and brain structure and function in a large human cohort study via deep phenotyping the participants: 1) objective measurement of physical activity using accelerometers over 2 weeks; 2) continuous blood glucose monitoring over 2 weeks, with two standard test meal during the 2 weeks, and traditional diet assessment with FFQ and 24h recalls; 3) measurement of cognitive function and brain images with the Addenbrooke's Cognitive Examination-Revised (ACE-R) and brain MRI; and 4) measurement of gut microbiome using metagenome and 16S rRNA sequencing techniques.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 45+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

Participants within the Guangzhou Nutrition and Health Study, without Alzheimer's disease, lived in Guangzhou, China, and aged 45 years or older;

Exclusion criteria

Participants with cancer and other serious medical disorders.

Trial design

Primary purpose: Prevention

Allocation: Randomized

Interventional model: Crossover Assignment

Masking: None (Open label)

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1,000 participants in 2 patient groups

Refined grain breakfast

Other group

Description:

white bread (100g) + milk powder (25g)

Treatment:

Other: Refine grain breakfast

Whole grain breakfast

Other group

Description:

plain oats (70g) + milk powder (25g)

Treatment:

Other: Whole grain breakfast