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Westlake Nutrition and Brain Health Study (WEBRAIN)

W

Westlake University

Status

Active, not recruiting

Conditions

Aging

Treatments

Other: Whole grain breakfast
Other: Refine grain breakfast

Study type

Interventional

Funder types

Other

Identifiers

NCT04135066
20190901ZJS0010

Details and patient eligibility

About

Westlake Nutrition and Brain Study (WEBRAIN) is a sub-study of the Guangzhou Nutrition and Health Study, a prospective cohort among participants living in Guangzhou city. The aim of the WEBRAIN is to investigate the relationship between diet, gut microbiome and brain health in the elderly individuals via deep phenotyping the participants including continuous blood glucose monitoring for standard test meal, objective physical activity measurement and brain magnetic resonance imaging.

Full description

The gut-brain axis has been considered a possible cause of neurodegenerative diseases via various mechanisms, and diet/nutrition has been linked to both gut and brain health. However, majority of related evidence derived from animal models or human study of small scale.

In the WEBRAIN, we aim to investigate the relationship between diet, gut microbiome and brain structure and function in a large human cohort study via deep phenotyping the participants: 1) objective measurement of physical activity using accelerometers over 2 weeks; 2) continuous blood glucose monitoring over 2 weeks, with two standard test meal during the 2 weeks, and traditional diet assessment with FFQ and 24h recalls; 3) measurement of cognitive function and brain images with the Addenbrooke's Cognitive Examination-Revised (ACE-R) and brain MRI; and 4) measurement of gut microbiome using metagenome and 16S rRNA sequencing techniques.

Enrollment

1,000 estimated patients

Sex

All

Ages

45+ years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Participants within the Guangzhou Nutrition and Health Study, without Alzheimer's disease, lived in Guangzhou, China, and aged 45 years or older;

Exclusion criteria

Participants with cancer and other serious medical disorders.

Trial design

Primary purpose

Prevention

Allocation

Randomized

Interventional model

Crossover Assignment

Masking

None (Open label)

1,000 participants in 2 patient groups

Refined grain breakfast
Other group
Description:
white bread (100g) + milk powder (25g)
Treatment:
Other: Refine grain breakfast
Whole grain breakfast
Other group
Description:
plain oats (70g) + milk powder (25g)
Treatment:
Other: Whole grain breakfast

Trial contacts and locations

2

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Central trial contact

Ju-Sheng Zheng, PhD

Data sourced from clinicaltrials.gov

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